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KMID : 0363219650040010007
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Korean Journal of Dermatology
1965 Volume.4 No. 1 p.7 ~ p.15
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Experimental Studies of the Effect of Testosterone on the Melanocytes and Melanin in the Skin
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金鐘渲/Kim, Jong Sun
이남주/朴秀淵/Lee, Nam Zoo/Pak, Soo Yun
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Abstract
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The hormonal control of melanin formation in the skin has aroused the attention of research workers for many decades. It is now generally accepted that en.locrine factors play an important role in melanogenesis in man and lower animals but it is surprising to find that although much experimental data has been obtained .it is still far from clear what action the male sex hormone has on melanin formation: Much of the obscurity probably stems from the fact that a great number of the observations have been macroscopic only and the microscopic studies have been confined to vertical sections. Vertical sections have the disadvantage that accurate melanocyte counts are impossible and that the appearances of the melanocytes cannot be adequately demonstrated. The present research is a controlled histochemical investigation into the effect of testosterone on the appearances of the melanocytes and melanin in the skin of the male rabbit using both skin sheets and vertical skin sections.
Fifteen rabbits were used for the investigation and these were divided into three groups (Immature, Mature and Orchidectomised) each consistsing of black and brown animals.
Skin samples measuring about 1.0 sq. cm, were taken from all the animals from the ear, anterior abdominal wall and sole of foot; in addition the right areola was excised. The animals were then given 5 mgm. of testosterone propionate (u, s, p, ) intramuscularly once daily for a period of 2 weeks in the case of the immature groups and for a period of 4 weeks in the case of the remaining groups. All the animals were killed by a blow on the occiput and a further series of skin samples were removed from areas adjacent to those taken previously and the left areola was excised.
The two skin samples from each region were observed by dopa reaction using the "skin-splitting" technic of Billingham and Medawar and hematoxylin-eosine stain.
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KEYWORD
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